Sefalosporinlere Direnç Mekanizmaları
Özet
Anti-mikrobiyal ilaçlara artan direnç gerek tedavi başarısızlığı ve bunun sonucu ortaya çıkan mortalite gerekse tedavi maliyetleri açısından önemli bir sağlık sorunudur. Beta-laktam ilaçlar arasında yer alan sefalosporinlere dört farklı mekanizmayla direnç ortaya çıkabilmektedir: beta-laktamları paraçalayan beta-laktamaz enzimlerinin varlığı, ilaç geçirgenliğinin azalması, ilacın dışarı atılması ve penisilin bağlayan proteinlerde değişiklik olması. Bu direnç mekanizmalarının detaylı bir şekilde bilinmesi tedavide uygun anti-mikrobiyal seçimine katkı sağlayacaktır.
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