Beta-Laktamaz İnhibitörlerinin ve Fusidik Asitin Etki Spektrumu ve Kullanım Alanları

Yazarlar

İlker Ödemiş
https://orcid.org/0000-0003-2638-0163

Özet

Beta-laktam antibiyotikleri hidrolize eden beta-laktamaz enzimlerini inhibe eden beta-laktamaz inhibitörleri, beta-laktam bir antibiyotikle birlikte kullanılan, dirençli bakteriyel enfeksiyonların tedavisinde yüksek etkinliğe sahip antibiyotiklerdir. Beta-laktam ve beta-laktamaz inhibitörü kombinasyonlarında etki spektrumunu belirleyen en önemli faktör beta-laktam grubu antibiyotiktir. Beta-laktamaz inhibitörleri farklı mekanizmalarla beta-laktam antibiyotiklerin beta-laktamazlar tarafından hidrolize edilmesini engelleyebilirler. Beta-laktam+beta-laktamaz inhibitörü kombinasyonlarının kullanım alanları, etki spektrumu, etki mekanizması, yan etkileri ve dozu farklılıklar göstermektedir. Preparatların tamamının özelliklerini klinisyenlerin takip etmesi oldukça zordur. Bu bölümde kullanımda olan ve gelecekte kullanıma girmesi beklenen beta-laktamaz inhibitörleri ele alınacaktır.

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