Tetrasiklinlerin ve Sülfanomidlerin Etki Spektrumları ve Kullanım Alanları

Yazarlar

İlkay Akbulut
https://orcid.org/0000-0002-4840-6865

Özet

Tetrasiklinler bakteriyostatik özellikte olup geniş spektrumunun içinde gram-pozitif bakteriler, gram-negatif bakteriler, hücre içi organizmaları ve parazitler de mevcuttur (1,2). Eravasiklin ve omadasiklin; etki mekanizması, yapısı ve etki spektrumu açısından tigesikline benzeyen, tetrasiklin sınıfından yeni antibiyotikler olup, dirençli suşlara karşı etkilidir (56,57). Kloramfenikol, birçok organizmaya karşı aktif olan ucuz fakat yanetki ve güvenirlik nedeniyle artık tercih edilmeyen bir ilaçtır (67). Trimetoprim kendi başına antibakteriyel aktiviteye sahip olan, folik asit sentezinin sıralı inhibisyonu yoluyla sülfonamidlerin aktivitesini güçlendirdiği düşünülen bir moleküldür. İklaprim, araştırma aşamasında olan yeni bir pirimidindir. Etki mekanizması, trimetopriminkine benzer, ancak 8 ila 32 kat daha fazla aktiviteye sahiptir (91).

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