Tetrasiklin ve Sulfonamid Direnç Mekanizmaları

Yazarlar

Ayfer İmre

Özet

Tetrasiklinlerin yaygın kullanımına bağlı ilaç direnci de artmıştır. Buna yönelik birçok tetrasiklin direnç geni tanımlanmıştır. Bu direnç genlerinin çoğu tet ve otr geni ailesindendir. Bu genler de, efflux pompaları, ribozomal koruma proteinleri, enzimatik inaktivasyon ile direnç geliştirir. Sülfonamidlere karşı direnç de çok yaygınlaşmıştır. Bunun önemli bir nedeni de farklı sülfonamidler arasında çapraz direnç oluşmasıdır. Direnç, kromozomal mutasyonlar ile ilaca dirençli enzimlerin üretimi veya azalmış bakteri geçirgenliği nedeniyle olabilir.

Referanslar

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23 Ocak 2023

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