Tetrasiklin ve Sulfonamid Direnç Mekanizmaları
Özet
Tetrasiklinlerin yaygın kullanımına bağlı ilaç direnci de artmıştır. Buna yönelik birçok tetrasiklin direnç geni tanımlanmıştır. Bu direnç genlerinin çoğu tet ve otr geni ailesindendir. Bu genler de, efflux pompaları, ribozomal koruma proteinleri, enzimatik inaktivasyon ile direnç geliştirir. Sülfonamidlere karşı direnç de çok yaygınlaşmıştır. Bunun önemli bir nedeni de farklı sülfonamidler arasında çapraz direnç oluşmasıdır. Direnç, kromozomal mutasyonlar ile ilaca dirençli enzimlerin üretimi veya azalmış bakteri geçirgenliği nedeniyle olabilir.
Referanslar
Roberts MC. Tetracycline therapy: update. Clinical Infectious Diseases. 2003;36:462-467. doi: 10.1086/367622
Chopra I, Roberts M. Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance. Microbiology and Molecular Biology Reviews. 2001;65:232-260. doi: 10.1128/MMBR.65.2.232-260.2001
Thaker M, Spanogiannopoulos P, Wright GD. The tetracycline resistome. Cellular and Molecular Life Sciences. 2010;67:419-431. doi: 10.1007/s00018-009-0172-6
Smith K, Leyden JJ. Safety of doxycycline and minocycline: a systematic review. Clinical Therapeitics. 2005;27:1329-1342. doi: 10.1016/j.clinthera.2005.09.005
Lebrun-Vignes B, Kreft-Jais C, Castot A, et al. Comparative analysis of adverse drug reactions to tetracyclines: results of a French national survey and review of the literature. The British Journal of Dermatology. 2012;166:1333-1341. doi: 10.1111/j.1365-2133.2012.10845.x
Fanning WL, Gump DW, Sofferman RA. Side effects of minocycline: a double-blind study. Antimicrobial Agents and Chemotherapy. 1977;11:712-717. doi: 10.1128/aac.11.4.712
Carney S, Butcher RA, Dawborn JK, et al. Minocycline excretion and distribution in relation to renal function in man. Clinical and Experimental Pharmacology and Physiology. 1974;1:299-308. doi: 10.1111/j.1440-1681.1974.tb00552.x
Speer BS, Bedzyk L, Salyers AA. Evidence that a novel tetracycline resistance gene found on two Bacteroides transposons encodes an NADP-requiring oxidoreductase. Journal of Bacteriology.1991;173:176-183 doi: 10.1128/jb.173.1.176-183.1991
Moore IF, Hughes DW, Wright GD. Tigecycline is modified by the flavin-dependent monooxygenase TetX. Biochemistry 2005;44: 11829-11835 doi: 10.1021/bi0506066
Diaz-Torres ML, McNab R, Spratt DA, Villedieu A, Hunt N, Wilson M, Mullany P. 2003. Novel tetracycline resistance determinant from the oral metagenome. Antimicrobial Agents and Chemotherapy.2003;47:1430-1432. doi: 10.1128/AAC.47.4.1430-1432.
Bialek-Davenet S, Lavigne JP, Guyot K, Mayer N, Tournebize R, Brisse S, Leflon-Guibout V, Nicolas-Chanoine MH. Differential contribution of AcrAB and OqxAB efflux pumps to multidrug resistance and virulence in Klebsiella pneumoniae. Journal of Antimicrobial Chemotherapy.2015;70:81-88. doi: 10.1093/jac/dku340
Hornsey M, Ellington MJ, Doumith M, Scott G, Livermore DM, Woodford N. Emergence of AcrAB-mediated tigecycline resistance in a clinical isolate of Enterobacter cloacae during ciprofloxacin treatment. International Journal of Antimicrobial Agents 2010;35:478-481. doi: 10.1016/j.ijantimicag.2010.01.011
Keeney D, Ruzin A, Bradford PA. RamA, a transcriptional regulator, and AcrAB, an RND-type efflux pump, are associated with decreased susceptibility to tigecycline in Enterobacter cloacae. Microbial Drug Resistance.2007;13:1-6. doi: 10.1089/mdr.2006.9990
Trieber CA, Taylor DE. Mutations in the 16S rRNA genes of Helicobacter pylori mediate resistance to tetracycline. Journal of Bacteriology.2002;184:2131-2140. doi: 10.1128/JB.184.8.2131-2140.2002
Brodersen DE, Clemons WM Jr, Carter AP, Morgan-Warren RJ, Wimberly BT, Ramakrishnan V.The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit. Cell.2000;103: 1143-1154. doi: 10.1016/s0092-8674(00)00216-6
Skold O. Sulfonamide resistance: mechanisms and trends. Drug Resistance Updates 2000;3:155-160. doi: 10.1054/drup.2000.0146
Huovinen P, Sundstro¨m L, Swedberg G, Sko¨ld O. Trimethoprim and sulfonamide resistance. Antimicrobial Agents and Microbiology. 1995; 39:279-289. doi: 10.1128/aac.39.2.279
Bushby SRM, Hitchings GH. Trimethoprim, a sulphonamide potentiator. British Journal of Pharmacology 1968; 33:72-90. doi: 10.1111/j.1476-5381.1968.tb00475.x
Kohler T, Kok M, Michea-Hamzehpour M, et al. Multidrug efflux in intrincid resistance to trimethoprim and sulfamethoxazole in Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy.1996;40:2288-2290. doi: 10.1128/aac.40.10.2288
Maseda H, Yoneyama H, Nakae T. Assignment of the substrate-selective subunits of the MexEI-OprN multidrug efflux pump of Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy.2000; 44:658-664. doi: 10.1128/aac.44.3.658-664.2000
Huovinen P. Trimethoprim resistance. Antimicrobial Agents and Chemotherapy.1987;31:1451-1456. doi: 10.1128/aac.31.10.1451
Dale GE, Broger C, D’Arcy A, et al. A single amino acid substitution in Staphylococcus aureus dihydrofolate reductase determines trimethoprim resistance. Journal of Molecular Biology. 1997; 266:23-30. doi: 10.1006/jmbi.1996.0770
Pikis A, Donkersloot JA, Rodriquez WJ, Keith JM. A conservative amino acid mutation in the chromosome-encoded dihydrofolate reductase confers trimethoprim resistance in Streptococcus pneumoniae. Journal of Infectious Diseases. 1998; 178:700-706. doi: 10.1086/515371
R de Groot R, Sluijter M, de Bruyn A, et al. Genetic characterization of trimethoprim resistance in Haemophilus influenzae. Antimicrobial Agents and Chemotherapy 1996; 40:2131-2136. doi: 10.1128/aac.40.9.2131
Adrian PV, du Plessis M, Klugman KP, Amyes SG. New trimethoprimresistant dihydrofolate reductase cassette, dhfrXV, inserted in a class 1 integron. Antimicrobial Agents and Chemotherapy.1998;42:21-24. doi: 10.1128/aac.42.9.2221
Charpentier E, Courvalin P. Emergence of the trimethoprim resistance gene dfrD in Listeria monocytogenes. Antimicrobial Agents and Chemotherapy.1997;41:1134-1136. doi: 10.1128/aac.41.5.1134
Padayachee T, Klugman KP. Novel expansions of the gene encoding dihydropteroate synthase in trimethoprim-sulfamethoxazole-resistant Streptococcus pneumoniae. Antimicrobial Agents and Chemotherapy.1999;43:2225-2230 doi: 10.1128/aac.43.9.2225
Swedberg G, Ringertz S, Skold O. Sulfonamide resistance in Streptococcus pyogenes is associated with differences in the amino acid sequence of its chromosomal dihydropteroate synthase. 1998; Antimicrobial Agents and Chemotherapy. 42:1062-1067 doi: 10.1128/aac.42.5.1062
Akiba T, Koyama K, Ishiki Y, Kimura S, Fukushima T. On the mechanism of the development of multiple-drug–resistant clones of Shigella. Japanese Journal of Microbiology 1960; 4:219-227. doi: 10.1111/j.1348-0421.1960.tb00170.x