Glikopeptitlerin Etki Spektrumu ve Kullanım Alanları
Özet
Bu bölümde incelenen vankomisin, hastaneye yatmayı gerektiren ciddi deri enfeksiyonlarında hala en önemli seçenektir ve MRSA'nın neden olduğu osteomiyelit, bakteriyemi ve endokarditte parenteral tedavi için olağan seçimdir. Telavansin, diğer ajanlar uygun olmadığında gram-pozitif patojenlerin neden olduğu deri ve yumuşak doku enfeksiyonu (DYDE) ve hastane kökenli pnömoni tedavisi için onaylanmıştır. Dalbavansin ve oritavansin, olumlu farmakokinetik özellikleri nedeniyle, gram-pozitif patojenlerin neden olduğu DYDE tedavisi için etkili ajanlardır ve sadece tek bir doz uygulamaya izin vermesi bir avantajdır. Bu strateji, DYDE’li hastaların önemli bir bölümünün hastaneye yatırılmasını önlemek için özellikle yararlı olabilir. İlaca dirençli gram pozitif enfeksiyonlarla ilgili daha fazla etkinlik çalışması gereklidir.
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