Oksazolidinonların ve Daptomisinin Etki Spektrumu ve Kullanım Alanları

Yazarlar

Damla Ertürk
https://orcid.org/0000-0002-2163-5844

Özet

Gram pozitif mikroorganizmalara bağlı enfeksiyonlar yumuşak doku enfeksiyonları, bakteriyemi, pnömoniler gibi sık karşılaşılan klinik tabloları oluşturur. Özellikle metisilin dirençli stafilokoklar (MRSA, koagülaz negatif stafilokoklar) ve vankomisin dirençli enterokoklar (VRE)’da tedavi seçenekleri sınırlıdır. Oksazolidinonlar ve lipopeptitlerden daptomisin gram pozitif enfeksiyonların tedavisinde yüksek başarı sağlayan antibiyotiklerdir. Oksazolidinonların oral ve parenteral kullanılabilmesi avantaj sağlamaktadır, dokuya geçişi oldukça iyidir. Uzun süreli kullanımında trombositopeni riski kullanımını sınırlayabilir. Daptomisin; gram pozitif etkenlere bağlı bakteriyemi ve sağ kalp endokarditi tedavisinde başarılı sonuçlar göstermektedir. En önemli yan etkisi revesible miyopatidir. Bu bölümde gram pozitif mikroorganizmaların tedavisinde kullanılan oksazolidinon grubu antibiyotiklerin ve daptomisinin etki mekanizması ve klinik kullanımları incelenmiştir.

 

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Gelecek

23 Ocak 2023

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