Oksazolidinonlara ve Daptomisine Direnç Mekanizmaları

Yazarlar

Azize Yetişgen

Özet

Oksazolidinonlar bitkilerdeki bakteriyel ve fungal enfeksiyonları iyileştirmek için geliştirilmiş ve daha sonra güçlü antibakteriyel etkileri ile insanlarda da kullanılmaya başlanmıştır. Birçok gram pozitif mikroorganizmaya etkilidirler. Bu sınıfın üyeleri; linezolid, tedizolid, radezolid ve sutezolid’tir. Muhtemel kullanılma süresi ve dozu ile ilişkili direnç gelişimide literatürde yerini almaya başlamıştır. Siklik lipopeptid sınıfının ilk üyesi olan daptomisin ABD’de 2003 yılında kullanıma girmiştir. Özellikle glikopeptid dirençli gram pozitif bakteriyel enfeksiyonların tedavisinde kullanılması önerilmektedir. Bazı bölgelerde yüksek vankomisin dirençli bakteriler saptanmaktadır. Bu bölgelerde daptomisinin yoğun kullanımı direnç sorununun başlamasına neden olmuştur. Bu bölümde oksazolidinonlara ve daptomisine dair bilinen direnç mekanizmalarından bahsedilecektir.

 

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23 Ocak 2023

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